After news reporter Danny Tanner's wife Pam is killed in a car crash by a drunk driver, he recruits his brother-in-law Jesse Katsopolis (an exterminator turned rock musician) and quirky best friend Joey Gladstone (who works as a stand-up comedian) to help raise his three daughters, D.J., Stephanie, and Michelle, in his San Francisco home. Over time, the three men as well as the children bond and become closer to one another.

In season two, Danny is reassigned from his duties as sports anchor by his television station to become co-host of a local morning television show, Wake Up, San Francisco, and is teamed up with Nebraska native Rebecca Donaldson. Jesse and Rebecca eventually fall in love, and get married in season four. In season five, Rebecca gives birth to twin sons, Nicky and Alex.

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