I'm gonna
disagree 
Chloe in 4x22 Lex went all
about bringing her down to the cave and making it look like he would harm her. so I can actually understand Chloe being all anti-Lex
Lois 
just the pureness of his running against Johnathon Kent considering how she sees them as the family she never had growing up. She cares A LOT about the Kents, so I can understand her judgement against Lex