If I remember correctly,
Iron Man 3 sets a specific year for the New Year's Eve party where Stark and Killian first meet, and then at least mentions the number of years that have passed between that meeting and the present, which would fix that movie's place in time. Other than that, Marvel has, for whatever reason, gone to great lengths to keep the
X-Men and
Avengers universes completely separate—to the point that they aren't even allowed to say the word "mutant" in the series, resorting to awkward phrases like "gifted individual."
Goof: In the episode's last scene, when we see Fitz approaching the group from behind, he is putting his right hand, which is clean, on his hip. But when the shot switches to show Fitz from the front, it is his left hand that is on his hip and his right hand which is covered with shaving cream.