TFTNT!
Castle/Beckett. They will always be my OTP. Everything about their story has been perfect.
Jo/Laurie. I'm rereading Little Women & Good Wives, and it renewed my love for them tenfold. I'll never convinced that they were not perfect for each other.
Harry/Ron/Hermione. One of the most wonderful friendships I've ever stumbled upon.
Hagrid/Harry. No one can get to Harry like Hagrid does, and viceversa. In my opinion, they share the closest bond in the series.