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ITA, this is the OTP of the show. It's been made very clear that Callie is the only woman for Jim and slowly vice versa for Jim for Callie. If this relationship wasn't significant then we would not get the build up we have we would have had rushed moments and the shoving of them together. But the writers believe in this pairing moreso even more because of Matt/Kiele's incredible chemistry.
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Maybe that's what inspired the love story line! Maybe when they first thought of the show they were going to include a nurse so there would be a main female character, but then when they saw the chemistry betw them they decided to develop it into a love relationship. I'd be curious to hear from the writers about that.