I didn't mind Dan and Serena at first but the show made Dan a lot less edgy in the show than in the books so I found him a bit of a turn off. And they were constantly shown as the "it" couple on the show, it got a bit irritating. And oh yes Serena's character was so different with him. I love her away from him and oddly enough enjoy their interaction as siblings
Nate/Death is all I can hope for. Poor Chase he's so pretty but ugh, Nate!
My usual:
-Cook/Effy
-Jack/Kate
-Sawyer/Juliet
-Annie/Anyone
-Joey/Anyone
-Buffy/Spike
-Xander/Anya