Charlie and Claire (lost)
Jack and Juliet (lost)
Cristina and Burke (GA)
Pacey and Andie (DC)
Izzie and Denny (GG)
Dylan and Brenda (90210)
Alex and Isabel (roswell)
Kyle from roswell because he didn't get a girl and stayed single for all the series
Pheebe and Cole (charmed)
Prue and Andie (charmed)
basically all the couples made by Nicholas Sparks since he's against happy endings and someone always dies
_-_