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I don't think people will know why Izzie and Callie are fighting because the affair isn't supposed to become public knowledge at the hospital until episode 5. I think Callie wants to have a chat with Izzie and that this is the face to face conversation Sara Ramirez hinted at in that ABC.com interview. I bet she still thinks George and Izzie just had sex and she's going to confront Izzie and they shall exchange words about them sleeping together, with Callie confident that it was just sex because George hasn't told her differently. Now of course, if Cagefighter Callie asked me to meet her in the cafeteria at noon all "let's duel"-like, I'd be thinking there could be a fight too. There won't be one though, I'll bet you anything.
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