Wayne Pygram/Raelee Hill(Scorpius/Sikozu from Farscape) Talk about sexual chemistry!
Hugh Laurie/Jennifer Morrison(House/Cameron from House)
Richard Shiff/Allison Janney(CJ/Toby from The West Wing) They are best friends in real life so that did help :-)
Eric Mccormack/Debra Messing(Will & Grace) I never shipped them because...you know...he's gay, but I LOVED the together as best friends. And Debra and Eric had amazing chemistry
Calista Flockhart/Robert Downey Jr(Ally/Larry from Ally Mcbeal)