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Same, to be honest I never bought Amy's real contribution on their paper.
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It wasn't so much that for me, but more of that was something the show always seemed to hint at was that the two of them would one day come up with something Nobel worthy, and then we DID get the Nobel storyling, but instead of it being between the two best friends and main characters, it of course has to be the married couple because if you're married in TV land you can't possibly have something super significant happen with a platonic relationship.
I'll always be a little bitter about it tbh.