Michael, Lincoln, Sucre, Sara Scofield and Co. may have removed the thorn in their side, the Company, but happiness is short-lived. The two-hour action spectacular begins with a trip down the aisle as Michael and a heavily pregnant Sara tie the knot. As ever, Lady Luck holds the lovebirds in disregard, and the newlyweds have no time to enjoy the delights of marital bliss. Michael is forced to cancel any honeymoon plans when Sara is arrested for the murder of Christina Scofield and, without so much as a trial, sent to Miami-Dade Women's Prison, where the Doc is reunited with Gretchen Morgan.

Meanwhile, General Krantz isn't adapting to his abode, Miami-Dade Men's Prison, but his mood soon brightens when he finds out about Sara's predicament. Krantz decides to while his hours of incarceration by plotting her demise, putting a mark on head for the princely sum of $100,000. Word soon reaches Miami-Dade Women's Prison, and a vulnerable Sara must fight for survival.

Michael, Lincoln, Sucre, and Mahone team up to break Sara out of prison. In the process, Michael is forced to stay behind and seemingly faces electrocution so that Sara can escape safely.