Well from how the first seasons went from the previous shows, they hinted the Hand would be the main villain, so my guess we won't know for certain until the shows start coming back. But from speculations going around two are tops as possibilities and wishful thinking.
The Hood
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Should The Defenders opt for a villain that bridges the gap between mysticism and the criminal underworld, The Hood might prove to be a good option. A crime boss and expert marksman, he has sported a cloak with invisibility and other powers. The New York-based supervillain has interacted with nearly all the key members of this particular version of the Defenders. Consider him a dark horse candidate to star in the Netflix miniseries. His comic book history with the Infinity Gems would also lend itself nicely to a crossover in the films if Marvel is willing to go that route.
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Mephisto
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Rumors are swirling that this Marvel villain — essentially the devil himself — will factor into the Netflix team up. Even though he seems like an outlandishly supernatural foe for the Defenders, the character would certainly bring new meaning to the devilish name of Hell’s Kitchen. For that reason alone, having him be the big bad for the Defenders feels a bit poetic to us.
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