Stephen Moyer as Reed Strucker: A father trying to balance his family responsibilities with his job as a district attorney.
Amy Acker as Caitlin Strucker: A mother struggling with her split from Reed and "increasingly challenging" teenage children.
Sean Teale as Marcos Diaz / Eclipse: A rebellious mutant who can absorb and manipulate photons.
Jamie Chung as Clarice Fong / Blink: A "sarcastic, lively" mutant with teleportation powers. The character was previously portrayed by Fan Bingbing in the film X-Men: Days of Future Past.
Coby Bell as Jace Turner: A man struggling with the cold-blooded requirements of his job.
Emma Dumont as Lorna Dane / Polaris: A brave and loyal mutant whose abilities include controlling magnetism.
Blair Redford as John Proudstar / Thunderbird: A strong-willed mutant, leader of the underground community.
Natalie Alyn Lind as Lauren Strucker: One of the series' central children, a "perfect" kid.
Percy Hynes White as Andy Strucker: One of the series' central children, a sensitive loner who keeps to himself.

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