Before seeing Fantastic Beasts I would've said she never recovered from the Muggle attack. But now with JK giving us more information, I think the abuse she sustained at Muggle hands added to her already existing problem of having an Obscurial inside of her.
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"Our lives shouldn't be measured by how much money we make or by how well known we are, but by how much fulfillment we can find in our everyday existence." ~ Ewan McGregor
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