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Yeah, he started to have issues with wife in the fall of 2014, which would be a few months before Derek got killed off. I do agree that whatever happened between Patrick and Jill did not reflect on him as an actor at all. He could have stayed on the show but taken a temporary leave while he dealt with his marital issues.
Yeah, about that, unfortunately, I don't think there really was much chemistry between Chyler and Ellen, which is why the writers never pursued the "Meredith's sister" bit beyond season 3. Ellen, Kelly, and Caterina have chemistry together, which is why the writers are focusing on it more now.
I do believe Lexie was the better sister than Maggie, though.
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