Basically something bad happened at GNB, and Barney's boss is blaming him for what happened and he might loose his job. He didn't tell anyone, the gang only found out because Marshall heard something about it at work.
So to keep his mind off of it, Barney's going for "The Perfect Week" - seven girls, seven night, no rejections, and is pretending nothing's going on.
But at the same time Barney's pretending to be having some conversation with some famous sports dude, I think, in his subconcious, and the other guy (who's just in Barney's head) comments that Barney really is just using the girls to distract himself and actually wants to talk about what's going on. Oh, and the guy even calls Barney a jerk, but since it's in Barney's mind, it's really Barney himself who thinks he really is a jerk. Poor guy has some serious issues
Oh! And even though it's played for laughs, Ted comments that Barney's whole life is a cry for help...